Rebound of COVID-19 Symptoms Rare After Nirmatrelvir/Ritonavir Treatment


THURSDAY, June 16, 2022 — Few patients experience rebound of COVID-19 symptoms after nirmatrelvir/ritonavir (NM/R) treatment, according to research published online June 14 in Clinical Infectious Diseases.

Nischal Ranganath, M.D., Ph.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues conducted a retrospective review among patients who received NM/R treatment for mild-to-moderate severe acute respiratory syndrome coronavirus 2. Data were included for 483 patients (median age, 63 years) who had a high risk for severe disease progression. Overall, 93 percent of the patients were fully vaccinated.

The researchers found that four of the patients (0.8 percent) experienced symptom rebound, defined as recurrence of COVID-19 symptoms following successful completion of five days of NM/R therapy, at a median of nine days after NM/R treatment. All four were fully vaccinated. None of the patients required hospitalization, and all improved without further treatment.

“Rebound after NM/R treatment is uncommon in our population of high-risk, but mostly nonimmunocompromised [patients],” the authors write. “Among the patients who developed rebound of symptoms after NM/R treatment, the clinical presentation was mild and did not require COVID-19 directed therapies.”

Abstract/Full Text (subscription or payment may be required)

© 2022 HealthDay. All rights reserved.

Further Support and Information on COVID-19

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.



Source link

Published by Drugs.Com Know More. Be Sure
Managed by Pharma Enthusiast, To claim this account, mail us at pharmamedia.in@gmailcom
Get Connected!
Come and join Pharma Community. Expand your network in Pharma!

Comments

No comments yet